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Get in Rhythm. Stay in Rhythm.® Atrial Fibrillation Patient Conference August 6-8, 2021, in Dallas, TX
Get in Rhythm. Stay in Rhythm.® Atrial Fibrillation Patient Conference August 6-8, 2021, in Dallas, TX

Video: Catheter Ablation Panel with Drs. Robert C. Kowal, Andrea Natale, Nassir Marrouche and Sanjiv M. Narayan

Cather Ablation Panel from the 2015 Atrial Fibrillation Patient Conference

November 3, 2015

The Catheter Ablation Panel at the 2015 Get in Rhythm. Stay in Rhythm.TM National Atrial Fibrillation Patient Conference included presentations by Robert C. Kowal, MD, PhD, FHRS, Chair; Andrea Natale, MD, FHRS; Nassir Marrouche, MD, FHRS; and Sanjiv M. Narayan, MD, PhD.

Dr. Kowal spoke about Pulmonary Vein Isolation (PVI) for Paroxysmal AF using Radiofrequency and Cryoablation [~00:00–22:00], including:

  • How pulmonary vein isolation came about
  • THERMOCOOL Study for treating paroxysmal AF (PAF) with radiofrequency (RF) catheters
  • Force-sensing RF catheters
  • Cryoballoon ablation of PAF, including outcomes with the second generation balloon and durability
  • Complications and limitations of radiofrequency vs. cryoablation

Dr. Natale spoke about Ablation of Paroxysmal and Non-Paroxysmal Atrial Fibrillation and Going Beyond PVI [~22:00–52:00], including:

  • Key determinants for procedural success
  • Pulmonary vein (PV) triggers
  • Left atrial substrate modification
  • Pulmonary vein antrum isolation
  • Circular mapping
  • Posterior wall isolation
  • CFAEs
  • Non-PV triggers
  • Coronary Sinus Tachycardia
  • Paroxysmal and persistent AF studies
  • Hybrid approach

Dr. Marrouche spoke about Using MRI to Better Treat AF Patients [~52:00–1:18:00], including:

  • Imaging atrial fibrotic tissue and predicting treatment outcomes
  • DECAAF centers and studies
  • Classification system based on degree of atrial fibrosis
  • Progression of fibrosis after treatment
  • Role of ventricular fibrosis in predicting treatment outcome
  • Isolated atrial myopathy
  • Detection of ventricular disease using LGE-MRI
  • PV triggers initiating AF
  • Non-invasive imaging and non-invasive mapping
  • Rotors and fibrosis
  • Isolating and ablating fibrotic tissue
  • DE-MRI guided catheter ablation of AF (DECAAF II)

Dr. Narayan spoke about Ablating Rotors Beyond Pulmonary Vein Isolation [~1:18:00–1:37:00], including:

  • Why do more than PVI?
  • Focal Impulse and Rotor Modulation (FIRM)
  • FIRM-guided ablation: single procedure
  • Am I a candidate? How do I choose a procedure?

There was an extensive Q&A [~1:37:00–1:55:00] that included the following topics:

  • Atrial flutter vs. afib
  • Right-sided and then left sided procedure?
  • Has stem cell research been considered?
  • Antidotes for new anticoagulants?
  • Correlation between long distance/endurance female runners and afib

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About Robert Kowal, MD, PhD, FHRS

Dr. Robert Kowal graduated from Yale University and received his MD and PhD degrees from UT Southwestern Medical Center. He completed his medical internship, residency and cardiology fellowship at Harvard Medical School/Brigham and Women’s Hospital and went on to study cardiac electrophysiology.

He currently practices at Baylor Heart and Vascular Hospital. While performing a broad spectrum of device implantation procedures, from pacemakers to multi-lead defibrillators, his main focus is the management of complex arrhythmias such as atrial fibrillation and ventricular tachycardia. His approaches involve both non-invasive medical therapy and catheter-based ablation procedures.

He has been and is currently involved in research on many cutting-edge technologies including cryoballoon ablation and FIRM mapping for atrial fibrillation, left atrial appendage closure and the role of renal denervation in the treatment of arrhythmia.

He has taken a national leadership role serving on the Board of Trustees at the Heart Rhythm Society and is on the editorial board of several scientific journals.

Andrea Natale, MD, FHRS, FACC, FESC

Patients from around the world seek treatment from Dr. Natale. A world recognized leader in the field of electrophysiology, Dr. Natale is a dedicated clinician, academician and researcher.

Prior to the establishment of Texas Cardiac Arrhythmia Institute at St. David’s Medical Center, Dr. Natale was a member of the Cardiovascular Medicine Department at the Cleveland Clinic from 1999 to 2007, serving most recently as Section Head for the Department of Cardiac Pacing and Electrophysiology and as Medical Director for the Cleveland Clinic’s Center for Atrial Fibrillation. In 2006, Dr. Natale was named to the Food and Drug Administration’s Task Force on Atrial Fibrillation.

A committed academician, Dr. Natale’s faculty positions at a variety of prestigious universities include Duke University and Stanford University. He has been an invited lecturer at more than 200 symposiums and conferences around the world, and is the author or co-author of hundreds of published articles on pacing and electrophysiology. In addition to serving on the editorial boards of numerous medical journals, he is editor-in-chief of the Journal of Atrial Fibrillation.

Dr. Natale’s greatest reward is restoring his patients to a life free of cardiac arrhythmia. He pioneered a circumferential ultrasound vein-ablation system to correct atrial fibrillation and performed the procedure on the world’s first five patients. He also developed some of the current catheter-based cures for atrial fibrillation, and was the first electrophysiologist in the nation to perform percutaneous epicardial radiofrequency ablation, which is a treatment for people who fail conventional ablation. He also holds a patent for a device used to treat Atrial Fibrillation.

A forefront researcher, Dr. Natale focuses on innovative advances in the treatment of atrial fibrillation. His goal is to benefit patient care through technologies such as robotic devices and specialized ablation catheters.

Nassir Marrouche, MD, FHRS

Dr. Marrouche has dedicated his career to developing innovative research and clinical practices to advance patient care, diagnosis and treatment of heart arrhythmias. In 2009, at the University of Utah, he created the Comprehensive Arrhythmia Research and Management Center (CARMA) bringing together a cross-departmental team of physicians, scientists, researchers, MRI and imaging specialists dedicated to working collaboratively to answer the questions: What if we treated patients proactively instead of reactively? Moreover, what if we could predict and prevent a stroke in a patient before it happens? Under the guidance of Dr. Marrouche, the CARMA Center developed the Utah Classification System enabling electrophysiologists and cardiologists to deliver individualized care to arrhythmia patients. In addition to presenting his work across the globe, he is the director of the Western Atrial Fibrillation Symposium.

Dr. Marrouche received his medical degree from the Medical School at the University of Heidelberg in Germany. Dr. Marrouche completed training in Internal Medicine and Cardiology at Klinikum Coburg, the teaching hospital of the University of Wurzburg in Germany. This was followed by a fellowship in Electrophysiology at the University of California, San Francisco. The Cleveland Foundation then offered a two-year fellowship in the Section of Pacing and Electrophysiology in the Department of Cardiovascular Medicine. After spending an additional three years at Cleveland Clinic as Associate Staff, he served as the Director of the Atrial Fibrillation Program at Klinikum Coburg for two years. Thereafter, he accepted a faculty position at the University of Utah serving as the Director of the EP Laboratories, Atrial Fibrillation Program, and later the Executive Director of the CARMA program.

Dr. Marrouche's research interests include the pathophysiology and new imaging modalities for treatment of atrial and ventricular arrhythmias.

Sanjiv Narayan, MD, PHD

Dr. Narayan is a practicing arrhythmia specialist (cardiac electrophysiologist) and Professor of Medicine at Stanford University where he directs the Atrial Fibrillation Program and Electrophysiology Research.

Dr. Narayan has developed a very active research program to discover the causes of human heart rhythm disorders, and use that information to improve treatment. In that way, funded by grants from the National Institutes of Health for nearly 15 years, Dr. Narayan’s group discovered rotors in human AF, and developed an approach to treat them by ablation (Focal Impulse and Rotor Modulation, FIRM). This approach has altered the way that physicians think about AF, and has been shown to be very effective by many groups.

Dr. Narayan is Associate Editor for the Journal of the American College of Cardiology and Journal of the American College of Cardiology: Clinical Electrophysiology Journal and Section Editor for Heart Rhythm Journal. Dr. Narayan trained in medicine and software engineering in England and became a fellow of the Royal College of Physicians of London. He was trained in neuroscience at the University of California Los Angeles, in Internal medicine at Harvard/Mount Auburn Hospital, then in Cardiology and Electrophysiology at Washington University in St. Louis. Dr. Narayan is board-certified in Internal Medicine, Cardiology and Clinical Cardiac Electrophysiology.

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Video Transcript:

Time markings are approximate

Robert C. Kowal: So to kind of give you an overview of what you're going to  hear from each of us, I want to introduce all the speakers now, and kind of the rough topic, so you can put it in a framework as you hear all the talks.

I'm going to talk about the technical aspects of actually doing a pulmonary vein isolation procedure, which is the cornerstone of afib ablation, as it stands now, and talk about radiofrequency catheters and the other approved catheter, which is the cryoballoon catheter, which we use quite a bit. Hopefully I won't put all of you to sleep, but it is going to be, by definition, kind of more than you wanted to know about how this works.

[00:01:00] The next speaker is going to be Dr. Natale. Andrea Natale was born in Italy and trained there and has been at Duke and at Lexington and now at — weren't you at Cleveland for years — and then now is in, sorry, that was 10 years, the 10 years we brushed by. He now does half his work in Austin and also San Francisco and also still in Italy.

I first met Andrea 13 or 14 years ago, when I hosted him for a talk and really wanted to pick his brain because he truly, with Michel Haïssaguerre and a couple others, was truly one of the pioneers of this field. While I talk about pulmonary vein isolation, he's going to talk about the fact that that's only part of the story. In a lot of patients, that's not enough.

He's done not only pioneering work in how to ablate the pulmonary vein area, but then how to find other triggering sites that are important to ablate, which is not easy to do. He's quite good at it.

[00:02:00] The next speaker after that will be Dr. Marrouche. Nassir Marrouche is from Lebanon, trained in Europe, has spent a bunch of time in Germany, then trained with Dr. Natale at Cleveland Clinic, and then was recruited by one of my former mentors to the University of Utah, where he is now, and really has done cutting-edge research, asking the question, if I can paraphrase for you, on what role does the anatomy of the atrium play in this whole process, focusing very specifically at the role of changes in the tissue where fibrosis occurs. Fibrous tissue replaces normal tissue, and then developing a whole strategy behind how to visualize that, and then has taken it full-circle, asking the question, "Once we know what that anatomy is, can we guide our therapy based on it?” So that's one major area that really he has pioneered in the afib ablation world.

[00:03:00] Then the last speaker will be Dr. Narayan. Sanjiv has done work in engineering, in neuroscience, in electrophysiology. He's been NIH-funded for many years. He has recently moved to Stanford, but has been many places and travels quite a bit. But he's come at this from a slightly different question/way. If I can paraphrase what you've been doing, I think it would be to say that, among the chaos and noise…I'm going to show you one of the slides of chaos and noise of afib… is there a way to find a window of organization among the chaos? I think if you summarize the work he's been trying to do, it is trying to find that needle in the haystack, that one area, or one of several areas, of signal among the vast array of noise. So that's another…he's launched yet another whole other area of research.

[00:04:00] So they're varied topics. I think you'll come out of here with your heads spinning. We always do in our meetings. Then it also shows you what some of the cutting-edge work is, but also, it introduces the fact that there's a lot we need to learn. So it will be an exciting two hours, I hope. Hopefully we can get them all arguing with each other too, because that's when it's really, really fun.

So I'm going to start by giving a hopefully not too mundane discussion of pulmonary vein isolation. So where did this all come about? If you pull back, Andrea would know this well, 15 or 20 years ago, if you asked —  well, not 15; 20 or 25 years ago — if you asked electrophysiologists, "Will we be ablating atrial fibrillation," there are a couple crackpots in the room who would say, "Yes," and the rest would say, "There's no way in the world.”

[00:05:00] Then Dr. Haïssaguerre in Europe, Dr. Natale, and some others, made some observations that, in fact, you could find single or multiple focus triggers that would trigger atrial fibrillation. This is depicted in this slide. What you're seeing is a 3D representation of the left atrium. The heart would be going back into the screen. The spine would be in front of us.

These are the pulmonary veins. These vessels coming in are what drain blood in from the lungs, and these were found to be hotspots. They could have little firing sites that would trigger atrial fibrillation within the atrium.

So, with this novel idea now, 17 years ago, that atrial fibrillation may not always be atrial fibrillation; it may be pulmonary vein-triggered arrhythmia. The reason for that is, if you did a cross-sectional cut through those veins, what you would see on the ridge is strips of muscle — these are little muscle fibers that have very cardiac-like properties — that could actually fire and beat, which was novel at that time.

[00:06:00] So this is now a 3D representation of the inside of the left atrium. What you have here is the chamber. These are the pulmonary veins coming into the chamber. This is the mitral valve going into the left ventricle. This is the left atrial appendage.

So when you saw that film earlier today of the Watchman device occluding the left atrial appendage, it's being put there. So now if we zoom in on one of these veins, the way to depict this is that there are muscle fibers depicted in red that go in and out of the veins, and then these little cross-fibers across that communicate. In sinus rhythm, there's impulses that go out into the veins and then kind of collapse and die because there's no more tissue to react.

[00:07:00] But then in some patients, you can have a site on one of those muscles fire rapidly and exit the veins to trigger atrial fibrillation. The little circular marker there is what we call the pulmonary vein ostium, which is a term you might hear, or the area being called the antrum, which is our way of trying to define the border zone of where the vein ends and the atrium begins, which is not always easy to define.

We can actually measure this. We can actually visualize this in the EP lab by putting in a catheter that has multiple electrodes, anywhere between usually eight and 20 at a time. We can make recordings of those activations in normal rhythm and then the firing. This is actually one of those recordings. So I'm going to walk you through this, and then you guys are all electrophysiologists after this.

[00:08:00] So this is a P-wave. This is an electrical activation of the atrium in a normal beat. Then this is what we see as signal on one of those circular, what we call a lasso catheter, and that wasn't because it was designed in Texas. It's just called a lasso catheter because of its shape. This is a normal beat.

What is going on here is this induction, this beginning of a chaotic activity that starts right here, the first activity starts right here in the pulmonary vein. That is pulmonary vein-triggering atrial fibrillation. When you see this, you know what the mechanism is. Unfortunately, we kind of rarely see this, but this is the basis behind this whole process of ablating afib through the years.

So this led to the idea of, "Can we prevent the entry and exit of those signals from the vein?" The first step was to say, "Okay. Let's see if we can ablate those fibers." So you have the catheter there, and you can record, in normal rhythm, the entry point into the veins by recording those fibers. Those markers there are electrical signals as a function of time.

[00:09:00] What you can do is make an ablation lesion at one of those early sites. What you'd see is that the activation, the timing of those electrical signals, would change. As you ablated this, this would be delayed. Now this site here, representing this fiber, was the early site at the vein. You'd ablate the rest of those.

What you'd do is you'd get rid of all signals going in and out of the veins. That’s what, when you hear the term "pulmonary vein isolation," that's what's being done. You're getting rid of the ability for signals, electrical signals, to go in or out of the veins. This approach was something called segmental isolation, because you're doing it in segments, and it works pretty well. Dr. Natale was one of the people who, early on, said, "This is not enough."

[00:10:00] That led to someone doing circumferential isolation, where we would do burning all the way around the vein. The idea there was, rather than kind of picking off piece by piece, you would get rid of the signals in one shot. Once you close that circle, you get rid of all the signals. That’s called pulmonary vein antral, or circumferential, isolation. That also works pretty well.

That was tested in a study called the THERMOCOOL Study, which was the first study that led to FDA approval of a catheter for treatment of paroxysmal atrial fibrillation. This slide depicts that study.

In this study, patients with paroxysmal afib, coming and going on its own, who had failed an antiarrhythmic drug, like flecainide or sotalol, were then randomized two-to-one, I think, to either a different antiarrhythmic drug or catheter ablation using a radiofrequency catheter that heats, and it is irrigated with saline for a variety of reasons, technical reasons we don't need to get into, but they're important, in conjunction with a three-dimensional mapping system to help us visualize where the catheter was.

[00:11:00] Now, what you see in the next panel is the results of the trial. So this is something called a Kaplan-Meier curve. We see these all the time. You should learn what these look like because, as you look at data, it's important to understand. What this is is the freedom from having atrial fibrillation, where one is 100%, and zero is 0%, over time.

What it really looks at is what percentage of patients are still free of the problem over time. It’s fairly sophisticated statistics, but what came out of this were two things. One, the drug therapy was abysmal. So once you failed an anti-arrhythmic drug, the likelihood of a second drug working is pretty low, 16% at one year. So it's unlikely to be effective.

[00:12:00] Now, ablation was much better, at 64%, meaning about 64% of people were free of atrial fibrillation, predominantly. It’s tricky because, in these trials, they're very, very regimented. Thirty seconds of atrial fibrillation would be a failure, even though you might have come in with daily episodes of atrial fibrillation.

So among that group that failed, the 36% that failed, there might have been people who were more than happy with the outcome, but by the technical rigors of that, only 64% were successful. So ablation was much better than drug in this setting, but there was still a lot to go. There was still a lot of improvement left to go. A lot of what our three speakers are going to be talking about is bridging that gap from the 64% on up.

[00:13:00] Now, one of those gaps has now come out using what are called contact force-sensing catheters. So when you have a catheter in the heart, we're controlling it from outside the heart, outside the body. These catheters will give you tactile feedback by telling you how hard you're pressing, so if it's too hard or not hard enough. When you use those, that success rate can go up to about the mid-70% range, realistically. So that's been a huge improvement just from this procedure alone.

But there are problems with trying to make a complete isolation process by going point by point. You can imagine. You'd rather draw a line than make a line out of dots. This is depicted here, and that is one of the problems. If you have a gap between any one of those ablation points, that's a setup for recurrent atrial fibrillation.

[00:14:00] So one of the major reasons why people recur, other than having sites that aren't related to the pulmonary veins, is the fact that we don't always get the pulmonary veins isolated in a durable manner.

The other aspect is this is hard to do. It's technically not easy. So while on a picture that I depict, it looks like this, in reality, the ablation points can look like this. If it's not complete, you can not only have repeat afib, but you can set up these little short circuits that are called atrial flutter. So some of you have heard about post-ablation atrial flutter. This is one of the reasons why it occurs.

So we want to make tight lesions that are compact. Dr. Marrouche will talk about this in some of his work. But when you look back at patients who come back with recurrent atrial fibrillation, or even all-comers, a good percentage of those veins have reconnected. It’s not because operators are bad; it's just it's hard to do.

[00:15:00] So this was one study, depicted by the pie chart, that as many as a third of patients who come back for a repeat ablation, even though at the time of their initial ablation the veins were isolated, a third of patients, none of those veins are isolated; another third, only one is.

In fact, there was a study in Germany with non-force catheters, with the original catheters, where they took a group of patients and either purposely made gaps or tried not to make gaps in those circumferential pulmonary vein sites, and then brought everybody back. Seventy-percent of the patients had some degree of reconnection of their veins, and a lot of that is associated with recurrent afib, not all, but a lot.

[00:16:00] So there's been a quest to figure out, among the whole process of afib, one aspect of the ways to improve this is can we get a better tool or another tool to help us get veins isolated. That's the rationale behind balloon-based therapies, which we've done some work with.

The idea there is, if you can use a balloon to deliver energy in one shot or two shots, can you get a more contiguous lesion? The only device that's approved thus far is a balloon that delivers cryo energy that we've worked with quite a bit. There’s another one still in trial that is used to deliver laser energy, and there was one that did not work very well because of complications that delivered ultrasound energy in the past.

So cryo energy is a little different from radiofrequency in that it freezes tissue instead of burning tissue. Because of that, it works a bit differently, in that the catheter sticks. So once it's frozen, it's stuck there during the lesion, and then it comes loose when it stops.

[00:17:00] It does less disruption of the underlying structure of the heart when it destroys the heart cells where we're ablating. That can be good, but it also can have a flip side that when we use cryo as a point catheter, the recurrence rates for certain things tend to be higher than radiofrequency.

So there's some pluses and minuses with the energy, but for this scenario, we liked what it has to offer. The way this is done, rather than making point-by-point burns around the vein, we have a catheter that has a wire. We put a wire in the vein. We inflate the balloon. We get contact all the way around, and then initiate a freeze lesion, and then do that again.

This is a similar kind of what we call a Kaplan-Meier curve, looking at an almost identical trial, using the cryoballoon instead of a point-by-point catheter. Again, what you see is that if you failed a drug for afib, your likelihood of having another drug successful is very, very low.

[00:18:00] But if you use this catheter, your success rate was about 70%. Now is 70% different from 64%? There's no way to know in something like this, because they're not head-to-head. What you know is they're at least in the range.

We went on to look at the learning curve for this. What we found was something really impressive, that by the time you did your 12th procedure, your success rate was quite high. Now does this mean everyone who's done more than 12 cryo procedures has a success rate of 90%? Absolutely not. In the setting of a controlled setting of a trial, we saw a nice progression in the fact that you can learn how to do this well with a fairly low procedure rate.

So since then, as there have been new generations of radiofrequency catheters, there are new generations of the cryoballoon catheter that are stronger. In green, what you can see is success rates around 80-plus-percent for paroxysmal atrial fibrillation, the earlier-phase atrial fibrillation.

[00:19:00] So one thing we've been impressed with was going back to this issue of the durability of pulmonary vein isolation. This is, again, not a comparison of two trials, but I want you to focus. I presented the GAP trial with radiofrequency before. There was a recent study, called SUPIR, looking at cryoballoon ablation of paroxysmal afib patients, and then bringing everyone back to the EP lab at three months to see who had pulmonary veins still isolated.

What was really nice was only 20% of patients who had cryoballoon ablation with the new-generation balloon had reconnection. Of all the veins, 91% of the veins remained isolated. So that's a big improvement.

[00:20:00] What we've seen is the following, in our experience, using cryoballoon. This represents about the first 263 cases with the second-generation balloon, followed for over a year, 488 days. We asked the question, not freedom from atrial fibrillation, but freedom from the need for a redo procedure, understanding that that's a very subjective doctor/patient discussion end point. But we thought it was relevant because as we look at cost of care, needing a second procedure or not is an important one.

What we found was that a repeat ablation rate was about 7%. When we looked at those patients, the vast majority of veins were still isolated. So that's one of the reasons why we've used this tool a lot for pulmonary vein isolation.

When you look at complications of radiofrequency versus cryoablation, they're very similar; some way more than others, but they're similar in what can go wrong.

[00:21:00] We can talk about that during question-and-answer. When I say it weighs differently, phrenic nerve injury that's transient is much more common with cryoablation than with radiofrequency, but it still can be there. There’s probably a little bit higher risk of esophageal injury with radiofrequency than cryo, but fortunately both of those are very, very low.

I think most people have really diminished the damage to the pulmonary veins quite well, and we've been able to lower a lot of these. When it comes to using blood thinners after these two approaches, they're pretty much identical. Most patients are on blood thinners after these procedures, at least for short-term.

The hard part is, while we feel that cryoballoon catheter is good for doing pulmonary vein isolation, there's very little information on using it for other aspects. So in patients who need additional lesions, when we come to the problem of what other catheters do you need to use, what other tools, and the cost of care.

[00:22:00] So I throw this out, I present this to you so you understand when your doctors say, "Pulmonary vein isolation," what we're talking about, and the idea that there are different tools that work differently to achieve a goal, but it's not right or wrong to choose one or another. It fits into a framework, a bigger picture of what needs to be done with your ablation. With that, I'm going to stop and then move to Dr. Natale, who’s going to talk about other things that need to be considered in an ablation.

Dr. Andrea Natale: There’s a lot of things that we're going to cover. I want to give you information that's really important for you as patients because there are a lot of different things that you see being discussed.

So first of all, one of the critical things that makes a good AF ablation program is the volume and the experience of the operator.

[00:23:00] This is where the field still is. Certainly, some of the technology that Robert discussed, like the balloon technology, helps in some way in bridging that gap. But still, experience is important in minimizing complications and achieving the best results you can with any tool you use.

Obviously, the balloon is a technology that really does a good job for paroxysmal, but the moment you start having more things outside of the pulmonary veins, you certainly have limited success with that approach.

Also, you need to make sure that the center has really a way to do the follow-up. So, there is a structure of people that are dedicated to that, nurses usually.

[00:24:00] The doctor usually is supposed to be busy in the lab, so a team of nurses that work with you from the education to the follow-up, but also that are involved in really making sure the follow-up is done.

This is an example of the follow-up that we have been using for many years, where patients are monitored with event recorders. Then, once they reach the critical end of the blanking period, if they're doing okay, then we establish a series of prolonged monitoring, usually seven days at a repeated interval. Now insurance is making that difficult.

Also, the event of implantable loop has changed. You need to make sure there is a follow-up. Otherwise, whatever you are told is based on whatever is published, not based on the local experience of the center.

[00:25:00] So, Dr. Kowal already mentioned about this. When it comes down to afib ablation, there is no one procedure that works for everybody. We're dealing with different patients and different substrates, and we talk a little bit about everything.

So essentially the procedure you do is important. We talked already about the experience of the operator, but there are a lot of sort of different situations that we can encounter that make everybody different. So we'll talk a little bit about that. Robert already mentioned about this.

In our group, actually one of the things that Robert mentioned was really the first to talk about this concept of antral isolation rather than segmental ostial. Over the years, we have learned that, yes, the pulmonary veins are important, especially in the paroxysmal group, but there is a variety of other structures, globally called the thoracic veins, which include the superior vena cava, the coronary sinus, the Ligament of Marshall, and then there are others. We'll talk a little bit about some of them because I think some of them are important in patients with nonparoxysmal AF.

[00:26:00] People also talk about substrate modification. As you will see, I'm not a big fan of that because substrate modification means deployment of empirical lesion, which sometimes works because, by chance, you affect an area that can be responsible for additional triggers. This is what our data suggests, but it's probably not the best approach, and now there is more data out there from properly-designed randomized studies.

So what do we target? So let’s start off with paroxysmal. Robert already mentioned about the pulmonary vein. One concept I want to explain to you, what he already mentioned, is the idea of the antral isolation. The antral isolation was considered not just because we wanted to avoid pulmonary vein stenosis but because we had clinical data. I’ll show you two, one from a randomized study from Germany, showing that antral has better result than ostial.

But also, we went there for three reasons. There is an embryologic reason.

[00:27:00] There is an anatomical reason. If you look at intracardiac echo, which our group was the first to promote, you actually see very clearly that the ostial isolation really doesn't include the posterior extension of the vein, which we call antrum, which you see there, outlined by the solid line.

We also heard about circular mapping. Another important thing about pulmonary vein is the way you do it. It's not just about deploying a lesion around the pulmonary vein to make an effective isolation; it's the way you do it. What the consensus document endorses is verification of isolation with circular mapping.

Why is that important? So you see that you have two procedures that look exactly the same. If you see the lesion deployment, it looks similar, but they are very different. In one, the one on your left, isolation was verified by circular mapping.

[00:28:00] The one on the right, which is called CPVI, the lesion end point was assessed by the same catheter that was used to deliver energy. So this is a procedure that some of you may know as the Pappone approach.

Well, when you deploy lesion in a circular fashion without using the circular mapping catheter, after the deployment of the lesion, the recording with the circular mapping catheter can look exactly the same as you see here. So although you deploy a lesion in a circular fashion, the veins are not isolated. This is something that actually many of us that tried have seen quite frequently.

This is actually a randomized study, comparing the two approaches, showing this much success at follow-up with the CPVA approach, 20% off antiarrhythmic drugs. So this is something I want you to understand. It's not just about doing something that looks similar; it's the way you do it.

So as I mentioned, in our lab, we always talk about antrum as something that involves the posterior wall between the veins.

[00:29:00] Why is that? As I mentioned, we have imaging data from the eyes, looking at real-time. We have clinical data. This is actually a paper that Dr. Marrouche published when we were in Cleveland, showing that when you do the ostial, and you challenge patients with a high dose of isoproterenol, you see more proximal triggers in a vast majority of those patients. That was sort of clinical information that prompted our group to do that, besides what we saw with imaging with eyes.

Another thing is that — this is from another group in Taiwan, showing the same concept — we can see that, embryologically, the posterior wall and the pulmonary vein come from the same class. So, it means that if the pulmonary vein can fire, so can the posterior wall between the veins, because it is the same group of cells that give origin to that structure.

[00:30:00] There is also data from the surgical literature. I like to show this. You’re going to hear Dr. Damiano and Dr. Edgerton, probably the two surgeons that I really trust because they're probably among the few surgeons that have really done a good job in monitoring their patients; they're very honest. So Ralph feels very strongly about the posterior wall. This is some of his data. I think some of his more recent follow-up still strongly supports this approach, which is very similar to what we've seen in our experience.

Rob already mentioned about this, so I'm not going to spend too much time besides saying that this, together with the balloon, is another technology that comes to help me be a less experienced operator and still do a better job. In fact, in this study, when operators stayed in the working force range, at least 85%, 80% or more of the time, success rate was stable around 80%. So this is important.

[00:31:00] We also look — this is a study we did in Europe — at what happens to people when we prove that the antrum is isolated. We look at two definitions of antrum, what most of the people do, which is sort of a larger circumferential versus ours. So you have this sort of standard of antrum versus ours. We look at our approach. This is the Kaplan-Meier Curve that Rob mentioned before.

So the one on the top is the posterior wall. So over time, there is a benefit by doing a more extensive antral isolation. It’s not huge, but it paid off after a few years follow-up. But despite that, you still see a significant number of patients, and those are all paroxysmal, that over three years, have recurrence, despite that we’ve proven that the area we targeted was isolated with a repeat study. So those recurrences are coming from non-pulmonary vein triggers. So this is even in paroxysmal. It happens sometimes over time.

[00:32:00] We actually again, to give you this idea because I think you need to know that, when we look at 10-year follow-ups in patients that have been doing okay for two years, we actually have seen that 13% — actually, now we wait a little longer — up to 20% of the patients develop recurrent atrial arrhythmia despite that the pulmonary veins are isolated. The presentation can be flutter or persistent AF or paroxysmal AF. Those are people that have done okay for between two to more than 10 years.

We've seen that the most common targets of recurrence are either the coronary sinus or the left atrial appendage. This seems to happen that the risk factors in this series were female, left atrial size, and the pre-existing scar, and you will hear this more and more.

[00:33:00] This is an example of one of these patients. When he came with his recurrence after many, many years, his posterior wall and pulmonary veins are isolated, and he had triggers — actually it was a she — from the left atrial appendage. So let me go quicker. I don't want to spend too much time.

Let's look at nonparoxysmal. As I mentioned, we do the pulmonary vein and the posterior wall. I already told you why the posterior wall so I'm not going to spend too much time — embryologic reason. We have data from the surgical leadership.

What about beyond that? I think, at least in our experience, we've established that that's a must in everybody. So what about beyond that? How do we go beyond that? As anybody, we look at the CFAE. Actually the CFAE, early on — it is a multicenter randomized study — shows some benefit with a single procedure.

In meta-analysis of those sorts of post-hoc analysis, pulling together all the studies with the same group of patients, sort of supported it.

[00:34:00] In the nonparoxysmal, the CFAE could have some benefit, not the same in paroxysmal. In paroxysmal, there was no benefit. But in the nonparoxysmal, there was.

Then you heard, I'm sure, about STAR-AF II showing that linear lesions of CFAE had a very similar outcome as the antral pulmonary vein isolation. However, you see a lot of recurrence there. They are the same. People can argue that maybe this operator was not very experienced, or they did not know how to deploy linear lesion or do the CFAE, but the bottom line is, with all three groups, there was a similar outcome. But still, you have almost 50% of the patients still coming back if you look at the end of that survival curve.

When we looked more recently at this group, we have seen that the CFAE do have an early sort of benefit, but it's not durable.

[00:35:00] The group that actually does the best long-term is the group where, once we've done the posterior wall and the pulmonary vein, we really spend a lot of time going after the non-pulmonary vein triggers. This is the group with the green line on top. The long-term follow-up does the best. The middle, in red, is the CFAE. The one at the bottom is just the posterior wall and pulmonary vein.

So, in the long-term follow-up, the only group that does better is the group where we really spend time doing it. Attention to triggers is what has become the standard in our lab and all the people that work with us.

This is an example of what I mean. This is a patient that had the posterior wall and the pulmonary vein isolated. Every time he stops his antiarrhythmic, he has a recurrence of organized atrial arrhythmia that, in this case, was coming from a trigger at the red spot at the top of the roof that you see there. That was a few more lesions to abolish the trigger, and the patient has done okay.

[00:36:00] This is the reason why I don't believe about this idea of the substrate, because substrate means just empirical deployment. This is a patient that already had a lot of substrate modification, but because there is a trigger outside that area that was targeted, we still have a recurrence. So those few isolations we deployed I don't think make a difference in an effective substrate modification versus not.

Which are the patients where we have to be more watchful about this? Severe left atrial scarring — Nassir will talk a lot more about that; nonparoxysmal AF; females; sleep apnea and obesity; LV dysfunction; and older age.

I'll show you this paper that we published in Octogenarian showing that even in the paroxysmal group, when you reach 80 years, and in females probably sooner than that — about 75, between 75 and 80 — the prevalence of non-PV triggers in the paroxysmal group is more than 60%, which means that if you just do the pulmonary vein, you're going to have barely 40% success in that group of patients. Those are straight paroxysmal, no other risks.

[00:37:00] Obviously, when you look at the nonparoxysmal, especially the longstanding persistent, it's virtually everybody. In the persistent group, we have a mix. We'll talk a little bit about that.

What are those non-PV triggers? The most common location is the coronary sinus. The second most common, in our experience, is the left atrial appendage. Then, interatrial septum, crista, and a variety of other locations.

Another issue that I think is important, that our community has neglected, most of the people that look at non-PV triggers, they go after only triggers that reinitiate sustained arrhythmia. Well, we have learned that that's not enough, especially when you use general anesthesia. You need to go after non-pulmonary vein triggers that are non-sustained, so consistent PAC, short bursts of tachycardia. This is the data that shows that.

So if you ignore those non-sustained triggers, your success rate, the bottom line, is going to be very low.

[00:38:00] So those mean something, especially if you use general anesthesia.

How do we sort of make those things going crazy? People have used different things. Isoproterenol high-dose is the most successful. High-dose means 20-30 mcg for at least 10 minutes, maybe 15. If you do 2–3 minutes of 5 mcg, it's a placebo effect. Adenosine, very rarely, sometimes.

Pacing, and pacing not to induce flutter, because with pacing, you can induce a lot of non-clinical atrium flutter; pacing to induce afib. Keep the patient in afib, cardiovert, and then hope that that sort of activates those triggers. So it's pacing more to induce AF. We do that if we have not good luck with isoproterenol or adenosine.

These are a few examples. Most of the time, at least at the beginning, when you see this trigger firing, once you're done — usually we do that once you've done the posterior wall and the pulmonary vein —they are, most of the time, rapid but organized arrhythmia.

[00:39:00] This is why, if these people have recurrence, they're going to have organized arrhythmia, not just because there  are gaps, but also because once you have isolated the posterior wall and pulmonary vein, they sort of sustain in a more organized fashion.

This is post adenosine. From this sequence of activation, this looks like something that starts from the right atrium.

Then another issue is what is the end point? So when you find the trigger, do you just ablate focally, or do you have to do more?

So there are a couple of sites where focal ablation doesn't work, and I'll show you which ones. Certainly the superior vena cava is one of them. We had data from a randomized study that we did with a group in Italy showing that, at least in paroxysmal, it paid-off to do empirical superior vena cava isolation. This is to show how we do it. We use the ICE. We put the circular catheter at the lower level of the pulmonary artery, and that's a good site to isolate without affecting the sinus node.

[00:40:00] Isolation is done the same way we do it for the pulmonary vein, until everything becomes silent above where you put the lasso.

Another site that I mentioned is the left atrial appendage. When we look at this, by just focusing early on to redo people that take 1–2 procedures, they come back in with the pulmonary vein isolated, so we've seen this to be the reason for re-initiation of sustained arrhythmia in about 27% of the patients. Now we have learned that we have to go after, as I mentioned, also the non-sustained firing from the location. But when we look at sustained arrhythmia, it was 27% of people coming for redo.

What we learned is that if we do focal ablation, even more than focal ablation until the activation of the appendage is delayed, that's not enough because those people eventually come back. It can take six years, sometimes one year, but they always come back.

So we learned that, unfortunately, isolation is the best strategy.

[00:41:00] Isolation has implications in long-term ability of discontinuing Coumadin. But if you are continuing to have arrhythmia, you're going to be on a blood thinner. So it's not trading off one problem for another. If it's important for the patient to get rid of the arrhythmia, it doesn't matter what you need to do.

We have data now from a non-randomized consecutive series in longstanding persistent showing the benefit of empirical isolation of the left atrial appendage. Now we just finished a randomized study, called BELIEF, in longstanding persistent where we randomized patients to empirical isolation of the left atrial appendage with the first procedure versus not. We just looked at the one-year follow-up, and we submitted this data. So we'll see. I think at some point, you will see this information out in the literature.

Ligament of Marshall is another potential target. Usually it's done by occluding the Ligament of Marshall and then injecting ethanol.

[00:42:00] You start from the distal component to the more proximal. This approach was sort of promoted by Dr. Valderrábano. We’re actually now with him doing a randomized study, sponsored by NIH, in persistent patients and we'll see what the outcome is.

The challenge with this approach is that cannulation of the Ligament of Marshall is not easy. Sometimes it takes just another hour just to do that. We have a significant number of patients where we could not do that, even after struggling for a while, but we'll see what the outcome is in the study.

Coronary sinus. I mentioned this, and this is a typical patient that actually looks like, with the pulmonary vein antrum, had the best outcome because his atrial fibrillation stopped by doing the antrum; but then, when we gave the 20 mcgs of isoproterenol, there he goes — he goes back into fibrillatory activation with firing from CS3 and CS4.

[00:43:00] You see that sort of little fragment very early as this restarts.

This is another example of a short burst of arrhythmia from the coronary sinus. The CS is another structure where focal ablation doesn't work well long-term. I had an example that I want to show, but we didn't have time, but this is another structure, like the appendage, that when you see firing, if you do focal ablation, it's not going to work long-term. So isolation can become the best strategy, but it's not trivial. It can take, just for that, like for the appendage, more than one procedure in almost half of the patients because of the way you have to deploy the lesion to avoid complication.

So Nassir is going to talk about this. This is a very old study, showing that in patients with scars, if you just do the pulmonary vein antrum, success rate is dismal. Nassir will talk about that.

[00:44:00] But what does it mean? Does it mean that those patients should not be considered for ablation? No, it means that pulmonary veins are not enough. Even pulmonary vein antral isolation is not enough in those patients.

We actually have data from this study, showing that even in paroxysmal patients, if you take the group with severe scarring, and you do just a standard PV antrum — this is an example of one of those patients — if you just do the standard PV antrum versus the PV antrum plus aggressive elimination of non-pulmonary vein triggers, there is a big difference.

So the group with the PV antrum only is virtually 80% recurrence of follow-up, whereas the other group does a lot better. So when you see severe scarring, it doesn't mean don't do the ablation; it means make sure that the person that is going to do your ablation is comfortable with going beyond the pulmonary vein, because that's really what those patients need. This is something — obviously this is a group of paroxysmal — but becomes much more prevalent in the nonparoxysmal patient.

[00:45:00] We also, like we did with the paroxysmal, in the persistent, we look at the benefit of doing just the PV antrum versus the non-PV trigger, and you see the difference. This was just presented recently at the AHA meeting — the American Heart Association meeting — showing that with a single procedure, going after the trigger beyond the pulmonary vein antrum in the dotted line paid off in the long-term freedom from AF, off drugs. Those groups were off drugs.

In the persistent group, we also looked at the same things I showed you before with the paroxysmal. We looked at so what if we prove posterior wall isolation? How is the follow up in those people?

[00:46:00] So I'll show you here. This is the cascade, people that came back, even if they were doing okay, were restudied until we proved that the posterior wall was isolated versus the sort of the antral. Then we looked at the follow up off drugs. I'll show you the Kaplan-Meier.

So even when you have isolated the posterior wall, which is the top line, the success rate is better than just doing the pulmonary vein antral leaving the posterior wall intact. But you still see a significant recurrence at follow up, almost 40%. So it means that in the persistent patients, there is a group that can do okay with the extended antrum isolation, but there is a significant group of about 40%–45% that needs attention to the non-PV trigger. When we go in the longstanding persistent, this number means goes to everybody.

Now I think Sanjiv is going to talk about focal sources. I want to mention a little bit about this. I think we're all excited about being able to do better, especially in the nonparoxysmal patient, with less ablation.

[00:47:00] I'm not going to spend time on how this is done because Sanjiv will show you that.

What I wanted to tell you is that, yes, it's good to be excited, but at the end, we still need good, solid data, which are not there yet, from multicenter randomized studies, to prove that this is sort of the way to go and the way to do that with different patients, so in the paroxysmal and the nonparoxysmal.

The same is true for this other approach that is being developed by a company called CardioInsight and has been tested in Bordeaux. They use a vest and from the outside map these focal sources. Then beyond doing the pulmonary vein, those sites are ablated. This is to give you an idea of the spread of the sites.

Also, so far, this approach has been tested only in consecutive patients. It is not a randomized study. Without a randomized study, it's very difficult to know what that does for your patient because you can select patients.

[00:48:00] As I showed you, they are persistent, they do okay with pulmonary vein antral isolation, but it doesn't work for everybody.

So if you don't have a randomized study where patients are allocated to different procedures in a random fashion, a consecutive series, it doesn't mean much.

I want to spend one word about this [hybrid approach] because now we see a lot of patients that, after they fail one procedure, or even without failing one procedure, they are offered the hybrid approach.

This is an example. The hybrid approach, for the most part, tries to target the posterior wall beside the pulmonary vein, which I believe is successful, but we actually — our group was the first to consider that not in just everybody — I don't think this should be done in paroxysmal. We used it in longstanding persistent. We stopped doing this because we did not see an increased success rate. Yes, our group has a lot of experience, so it might be different in somebody else's hands. But also, we saw a higher rate of complication. So, therefore, I don't think there is any role for a true hybrid.

[00:49:00] It doesn't mean that people should not have surgery, but do the surgery; then, if the surgery doesn't work, two, three, four months after, you go and have a catheter ablation to touch up whatever.

The hybrid approach, which means that the same day you have both the surgery and the catheter procedure, increased the rate of complication. It is a logistical nightmare. You are going to be under general anesthesia for probably 10 hours or longer because you're going to be under general for the surgical part and for the catheter-based part.

I don't think there is any role for the true hybrid. There is a role for surgery. Then if the surgery doesn't work, months later, you have the catheter procedure.

Well, I'm not going to show you this, and not even this.

[00:50:00] Let's go to the end, which is the summary of what I told you. Yes, the pulmonary veins are important, mostly in the paroxysmal. But as we move in the nonparoxysmal group, the presence of other sources of atrial fibrillation becomes more and more important. They need to be addressed if you wish to achieve a high success rate off antiarrhythmic drugs.

So this is a summary. Adjunctive strategy to either PVI or PV antrum, which includes linear lesions or CFAE — only a short-term increased success in patients with nonparoxysmal AF. Isolation of the pulmonary vein, although insufficient, is important. So even if it's not all of it, it needs to be done; but in the nonparoxysmal group especially, it's not the end of the story.

[00:51:00] In that group, identification of a trigger outside the antrum with high dose of isoproterenol is important to achieve a long-term cure of atrial fibrillation. The role of additional targets — this is very important for you as a patient — needs to be verified in properly designed studies.

So after all, it's important to have the right tool. The right tool is different in everybody, in different hands. So Robert mentioned the cryo. It's a good tool for certain people, as long as it's used properly, so for the paroxysmal patient, not for the nonparoxysmal. It’s also important to keep your eye on the target, because it's not just about one target in many patients. Thank you very much.

Nassir F. Marrouche: So you heard from Andrea and Rob, two major players in the field of afib. Andrea Natale, I did my fellowship with him, and worked there for a while. You see how many approaches — we're still trying to debate what's the best way to ablate atrial fibrillation. How many in the room here today had an afib ablation done?

[00:52:00] Raise your hand. How many have afib as a disease? So I would say half of you have been ablated, and the rest is still waiting for Andrea's waiting list probably. Right? That’s the status.

So what I want to do today, I want to share with you the substrate. Obviously, one positive of this afib concept we all know about, the atrial fibrosis, or atrial substrate, is how we use this and manage this, and what we learned the last almost 10 years now in Utah since we left Cleveland.

Andrea showed you a slide that's a very important slide, this CARTO map. You know what a CARTO map is; it’s a 3D image reconstruction with the scar.

We knew this for a long time when we were in Cleveland. We got these hearts, and there's so much scarring, and what Andrea's trying to say, "It's the triggers — there's something — look for triggers," which is true. There's something going on that we don't know yet. Sanjiv will talk about the rotors. But I want to show this — why this concept of MRI?

[00:53:00] MRI obviously is easy to reproduce. It's a very great instrument in detecting soft tissue, and that's why we focus on this.

So I talk about how we image the fibrotic changes in the hearts. Everybody in this room — the people who raised their hands, and the people who did not raise their hands — they have different hearts, different anatomy, and different structures, and risk factors and comorbidities that define us where we are today. These changes are happening now.

So when I talk about this, how we predict treatment outcomes, not only afib ablation, which is … Sanjiv just shared with me the latest number is 150,000 people ablated in America every year — by the way, 10% are ablated by Andrea in Austin, and the rest of the United States. But anyway, it's 150,000 out of six or seven million afibbers.

I think if you look more into the hearts, we start defining, convincing you I think to ablate earlier than later, based on the structure and the tissue changes.

[00:54:00] I think this could be half-a-million to a million people that we can help early on in the disease progression.

I want to show you some data and how we're using a treatment target, and this is in the process, hopefully, of being standardized. So this is the way we do this. This is a paper published last year. So you see this from the screen, we do an MRI scan. By the way, this was 10 years ago — it was only in Utah. Now, just ask for it — Siemens and Philips and GE can offer this.

But this is an MRI scan that you do a specific way to look at the atrial wall, the thin atrial wall seen here. We define how much damage we have. So the summary is seen in this slide. It's green and whitish, gadolinium, or cleaning up or flow — this means more diseased tissue. The blue is healthy tissue.

So this is how we detect it, using that sequence. If you want to look at it further, this is a paper published — actually, there are 28 papers published describing this way, from other labs as well.

[00:55:00] So this is an important paper, one of the most important papers, that we published from our lab describing this, because this correlated open heart surgery findings to the screens. So these are tissue from patients who underwent either mitral valve surgery or bypass surgery, whatever it is, and then we took biopsies from these areas to correlate the findings to what we see in MR.

You see this is a control (no-afib) patient, and this is a patient with atrial fibrillation. So this slide, the paper published by McGann two years ago, that's showing that this is what we see, changes that are fibrotic. The more green, the more dense the fibrosis, the more dense the changes in your heart; the less green, the less changes are there, as you see here, for example, less. This is a healthy area where there's no fibrosis.

Again, this is one of the most important papers we published because we correlated these findin

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Last Modified November 2, 2015

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